Volumetric microdetermination of sulphonamides

The metabolism of sulphonamides.

p-Aminomethylbenzenesulphonamide (I) was first described by Miller, Sprague, Kissinger & McBurney (1940), and is used in therapy as its hydrochloride, Ambamide (formerly Marfanil). Its antibacterial properties were studied by Klartr (1941) who found it to be less active than sulphanilamide against streptococci, but more active against anaerobic bacteria (cf. Schoop & Stoltz, 1941 Hamre, Walker,...

Photometric Microdetermination of Human Gamma

The main purpose in performing the detailed experimental studies in Part I is the application of the photometric method to the determination of the gamma globulin content of human sera. These experimental studies show that protein fractions such as albumin or alpha globulins, whose electrophoretic mobilities are far removed from gamma globulin, cause little interference with its determination. ...

Microdetermination of Proline in Serum.

An accurate method for determination of proline in serum has been adapted to a micro scale, with good results. Acidic ethanol is used as a serum deproteinizing agent prior to development of color with ninhydrin and its extraction into benzene. The range of accuracy is ± 3.0% with as little as 0.2 ml. serum. The microdetermination of this amino acid facilitates study of the intermediary metaboli...

Sulphonamides: A Pharmaceutical Review

Sulphonamides are the first effective chemotherapeutic agents used for bacterial infection in humans. Sulfonamides have a wide range of pharmacological activities such as Oral hypoglycemic, antileprotic, anti epileptic, anti-hypertensive, anti-bacterial, anti-protozoal, anti-fungal, anti retroviral, anti cancer, antiinflammatory, and used as diuretic. This review consists of a discussion on the...

Sulphonamides in Undulant Fever